Hi Joe Cody, Yes you can use the RS232 #2 for programming via 505Workshop while RS232 #1 is connected to Wonderware. It is not an ill-advised at all. Otherwise you may consider the new CPU offered by CTI that comes with three (3) communication alternative USB, Serial and Ethernet. You may find more information at http://www.controltechnology.com/ If you want more information, i can roughly share it with you over here upon your request. Regard Chee Ming