The most common problem is using commercial off-the-shelf cables between the PLC and USB converter. Omron does not use standard pinouts on most RS-232 connectors. Never plug the RS232-USB converter directly into the PLC.
Prefabricated cable: C200HS-CN220, or make your own:
Use a DB9 Male cable connector to mate with the Female PLC Serial Port, use a DB9 Female cable connector to mate with the Male PC Serial Port
PLC<------>PC
2<--------->2
3<--------->3
9<--------->5
On PLC connector only, Jump together pins 4 & 5
On PC connector only, Jump together pins 4 & 6, jump together pins 7 & 8
Leave all other unspecified pins unconnected
Solder shield or drain wire only to the metal hood of the PLC connector, do not connect other end.
If the Omron-side plug must be fastened down, please order connector kit CJ1W-CN001, which includes one male connector body, back-shell and hardware. Omron devices use non-standard metric jackscrews, whereas most American connectors come with 4-40UNF threads which won't fit.