Dear All - Hope this helps somebody.
When I reported to work this AM I was immediately paged to one of our packaging machines. The HMI was obviously not communicating with the PLC. My Laptop coudl access the PLC and see the logic executing. It could likewise RADMIN control the HMI PC. I'd seen this issue once before and it was a Coms Server Lockup I was told by the engineer who designed the machine.
"Reboot the PC and all will be well"
LOL HA HA LOL
After rebooting I could not RADMIN the PC, but it had an IP address and all lights on the NIC looked ok. The PLC was still available just fine. A couple of hours later when out IS Department showed up the "fixed" the machine by turning off Symantec Firewall which had been turned on during the reboot. They can't explain why, but I thought it was fun.